C-Trap Dymo 400. Optical Tweezers-Fluorescence Microscope

The University of Birmingham, within the College of Medicine and Health, is expanding its capabilities for advanced single-molecule biophysics research. This expansion includes the acquisition of a highly specialised instrument: the C-Trap® Dymo 400, manufactured by LUMICKS B.V. This instrument integrates cutting-edge optical trapping, confocal fluorescence microscopy, and laminar flow microfluidics into a single, coherent system.

The C-Trap® Dymo 400 will be installed at the University to support high-precision, real-time studies of molecular interactions, particularly in areas involving DNA-protein complexes, RNA structures, ubiquitin structures and cytoskeletal filament dynamics. It includes multi-colour confocal fluorescence (488, 561, 638 nm), dual force detection (x,y), short tether capabilities, microfluidics, and full system integration with proprietary Bluelake software, all required to maintain the scientific edge of our ongoing biophysical and molecular biology research.