Elyra 7

With the recently developed Lattice SIM2 technology, there is a clear opportunity to broadly deploy SR at the new Institute for Regeneration and Repair (IRR) at the Edinburgh bioQuarter campus. Our ability to track dynamic cellular processes has been transformed by new tools and techniques that have emerged from genetics (CRISPR), stem cell biology (iPSCs and organoids), and synthetic biology (genetic circuits and reporters). These can be combined with super-resolution (SR) imaging capabilities to gain deep mechanistic insights into human disease mechanisms and support drug discovery (target validation).

We are therefore seeking support to purchase the Zeiss Lattice SIM2 SR microscope. This will open possibilities for many MRC funded research groups to routinely perform live cell super-resolution imaging across a range of physiological samples, scales and models.