Genome Plasmid
key details
| Value | USN 75,135 |
|---|---|
| Status | complete |
| Category (CPV) | 33140000 |
| Procedure | open |
| OCID | ocds-r6ebe6-0000801998 |
Award
| Supplier | Value | Date | Status |
|---|---|---|---|
| Indiana University | · | · | · |
description
We are planning a clinical trial to treat a rare genetic disease that causes progressive dementia in children. Our therapy is based on the following: Autologous haematopoietic stem progenitor cells (HSPCs) are modified ex vivo with a lentiviral vector (LV) to express supraphysiologic levels of a secreted enzyme in myeloid progeny, in essence using gene-modified monocytes/macrophages as a durable and effective vehicle for central nervous system (CNS) enzyme delivery.
In order to progress this therapy, we require the following; a plasmid to our specification, produced to FDA, IND ready standard for use in the manufacture of a lentiviral vector for clinical trial. This Plasmid will be delivered directly from the supplier to the University of Edinburgh’s partner in the project, University of California Los Angeles.
documents
- Genome Plasmid , awardNotice
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source
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