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Microcirculatory changes during haemorrhagic shock in relation to shock and subsequent inflammatory responses

Defence Science and Technology Laboratory Published 27 Oct 2021 Contracts Finder
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key details

Value£54,992
Statuscomplete
Category (CPV) 73111000
Deadline17 Sept 2021
Contract start20 Sept 2021
Contract end31 Aug 2022
Procedureselective
SME suitableNo
OCIDocds-b5fd17-f00d81b7-9ef7-4f8a-b794-f7bfb4e3b52d

Award

SupplierValueDateStatus
King's College London £54,992 10 Oct 2021 active

description

The cardiovascular response to trauma (tissue injury, haemorrhagic shock and resuscitation) leads to inflammatory responses that can either cause further damage or underpin subsequent tissue healing. A novel element of the inflammatory response is the interaction between platelets and neutrophils, which have been examined in a collaborative pilot study with King's College, who have expertise in neutrophil-platelet interactions. The inflammatory response in trauma is in part orchestrated by the microcirculation. There is considerable inter-individual variation in the microcirculatory response to trauma. A detailed assessment of these responses, followed by correlation with the systemic physiological and inflammatory responses, may identify mechanisms of response and potential therapeutic directions to modify the inflammatory response and augment the potential for healing.

notice history

1 notice published against this procurement.

PublishedTypeRegimeNotice
27 Oct 2021 Award (award) · a7226318-3f6d-4251-b405-2014f4c2cf80-480234

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