RFQ - Preparative HPLC
key details
| Status | active |
|---|---|
| Category (CPV) | 38000000 |
| Region | London |
| Deadline | 6 Nov 2020 |
| Contract start | 30 Nov 2020 |
| Contract end | 1 Nov 2021 |
| Procedure | limited |
| SME suitable | Yes |
| OCID | ocds-b5fd17-bd69fc46-6497-4b2a-8172-a9bc30e8db8e |
description
The National Physical Laboratory (NPL) requires automation to facilitate the purification of peptides which have been synthesized via 9-Fluorenylmethoxycarbonyl (Fmoc) Solid Phase Peptide Synthesis (SPPS). Due to the intrinsic nature of this synthetic technique, it is quite common to isolate crude peptides as a mixture of the desired product and closely related impurities (e.g. protecting group adducts / deletion sequences).
NPL tends to synthesize difficult peptides (self assembling, repeating motifs, slightly insoluble sequences) on 0.1 mmol scale via microwave assisted Fmoc SPPS; yielding 150 mg to 400 mg of crude product after resin cleavage. NPL is seeking to purchase a preparative HPLC, which will facilitate the purification of larger quantities of crude peptide per run (than we are currently able, i.e. >> 15-20 mg per un); and therefore yield greater quantities of highly pure peptides.
Additional information:
Please do not contact the person listed on this notice. Documents can only be obtained through Bravo Solutions.
documents
- https://lupc.bravosolution.co.uk/web/login.shtml , tenderNotice
- https://www.contractsfinder.service.gov.uk/Notice/d995b521-cba1-4fe2-b58c-b74bcab1f139 , tenderNotice
Documents are linked, not mirrored. They are served by the publishing authority and may require registration.
notice history
1 notice published against this procurement.
| Published | Type | Regime | Notice |
|---|---|---|---|
| 23 Oct 2020 | Tender (tender) | · | d995b521-cba1-4fe2-b58c-b74bcab1f139-389157 |
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source
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